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Feasibility of somatostatin receptor-targeted imaging for detection of myocardial inflammation: A pilot study.
Bravo, Paco E; Bajaj, Navkaranbir; Padera, Robert F; Morgan, Victoria; Hainer, Jon; Bibbo, Courtney F; Harrington, Meagan; Park, Mi-Ae; Hyun, Hyewon; Robertson, Matthew; Lakdawala, Neal K; Groarke, John; Stewart, Garrick C; Dorbala, Sharmila; Blankstein, Ron; Di Carli, Marcelo F.
Afiliação
  • Bravo PE; Cardiovascular Imaging Program, Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. paco.bravo@uphs.upenn.edu.
  • Bajaj N; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. paco.bravo@uphs.upenn.edu.
  • Padera RF; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. paco.bravo@uphs.upenn.edu.
  • Morgan V; Divisions of Nuclear Medicine and Cardiology, Departments of Radiology and Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. paco.bravo@uphs.upenn.edu.
  • Hainer J; Divisions of Nuclear Medicine and Cardiology, Departments of Radiology and Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 11-154 South Pavilion, Philadelphia, PA, 19104, USA. paco.bravo@uphs.upenn.edu.
  • Bibbo CF; Cardiovascular Imaging Program, Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Harrington M; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Park MA; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Hyun H; Division of Cardiology, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Robertson M; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Lakdawala NK; Cardiovascular Imaging Program, Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Groarke J; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Stewart GC; Cardiovascular Imaging Program, Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Dorbala S; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Blankstein R; Cardiovascular Imaging Program, Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Di Carli MF; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
J Nucl Cardiol ; 28(3): 1089-1099, 2021 06.
Article em En | MEDLINE | ID: mdl-31197742
ABSTRACT

BACKGROUND:

Gallium-68 Dotatate binds preferentially to somatostatin receptor (sstr) subtype-2 (sstr-2) on inflammatory cells. We aimed at investigating the potential clinical use of sstr-targeted imaging for the detection of myocardial inflammation.

METHODS:

Thirteen patients, with suspected cardiac sarcoidosis (CS) based on clinical history and myocardial uptake on recent fluorine-18 fluorodeoxyglucose (FDG) PET, were enrolled to undergo Dotatate PET after FDG-PET (median time 37 days [IQR 25-55]). Additionally, we investigated ex-vivo the immunohistochemistry expression of sstr-2 in 3 explanted sarcoid hearts.

RESULTS:

All FDG scans showed cardiac uptake (focal/multifocal = 6, focal on diffuse/heterogeneous = 7), and 46% (n = 6) extra-cardiac uptake (mediastinal/hilar). In comparison, Dotatate scans showed definite abnormal cardiac uptake (focal/multifocal) in 4 patients, probably abnormal (heterogenous/patchy) in 3, and negative uptake in 6 cases. Similarly, 6 patients had increased mediastinal/hilar Dotatate uptake. Overall concordance of FDG and Dotatate uptake was 54% in the heart and 100% for thoracic nodal activity. Quantitatively, FDG maximum standardized uptake value was 5.0 times [3.8-7.1] higher in the heart, but only 2.25 times [1.7-3.0; P = .019] higher in thoracic nodes relative to Dotatate. Ex-vivo, sstr-2 immunostaining was weakly seen within well-formed granulomas in all 3 examined sarcoid heart specimens with no significant staining of background myocardium or normal myocardium.

CONCLUSION:

Our preliminary data suggest that, compared to FDG imaging, somatostatin receptor-targeted imaging may be less sensitive for the detection of myocardial inflammation, but comparable for detecting extra-cardiac inflammation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Sarcoidose / Receptores de Somatostatina / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Miocardite Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Sarcoidose / Receptores de Somatostatina / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Miocardite Idioma: En Ano de publicação: 2021 Tipo de documento: Article