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Nickel-catalyzed monofluoromethylation of (hetero)aryl bromides via reductive cross-coupling.
Yin, Han; Sheng, Jie; Zhang, Kai-Fan; Zhang, Zi-Qi; Bian, Kang-Jie; Wang, Xi-Sheng.
Afiliação
  • Yin H; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xswang77@ustc.edu.cn.
  • Sheng J; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xswang77@ustc.edu.cn and School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, Guangdong
  • Zhang KF; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xswang77@ustc.edu.cn.
  • Zhang ZQ; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xswang77@ustc.edu.cn.
  • Bian KJ; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xswang77@ustc.edu.cn.
  • Wang XS; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xswang77@ustc.edu.cn.
Chem Commun (Camb) ; 55(53): 7635-7638, 2019 Jul 07.
Article em En | MEDLINE | ID: mdl-31198913
ABSTRACT
A mild and efficient nickel-catalyzed direct monofluoromethylation of (hetero)aryl bromides by reductive cross-coupling has been developed. This method exhibits good efficiency, wide functional-group compatibility, and suitability for aryl and heteroaryl bromides with abundant industrial raw material BrCH2F. This strategy provides an efficient way to synthesize monofluoromethylated molecules for drug discovery.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article