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XX sex chromosome complement promotes atherosclerosis in mice.
AlSiraj, Yasir; Chen, Xuqi; Thatcher, Sean E; Temel, Ryan E; Cai, Lei; Blalock, Eric; Katz, Wendy; Ali, Heba M; Petriello, Michael; Deng, Pan; Morris, Andrew J; Wang, Xuping; Lusis, Aldons J; Arnold, Arthur P; Reue, Karen; Thompson, Katherine; Tso, Patrick; Cassis, Lisa A.
Afiliação
  • AlSiraj Y; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, 40536, KY, USA.
  • Chen X; Integrative Biology and Physiology, University of California, Los Angeles, 90095, CA, USA.
  • Thatcher SE; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, 40536, KY, USA.
  • Temel RE; Saha Cardiovascular Research Center, University of Kentucky, Lexington, 40536, KY, USA.
  • Cai L; Department of Physiology, University of Kentucky, Lexington, 40536, KY, USA.
  • Blalock E; Saha Cardiovascular Research Center, University of Kentucky, Lexington, 40536, KY, USA.
  • Katz W; Department of Physiology, University of Kentucky, Lexington, 40536, KY, USA.
  • Ali HM; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, 40536, KY, USA.
  • Petriello M; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, 40536, KY, USA.
  • Deng P; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, 40536, KY, USA.
  • Morris AJ; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, and Lexington Veterans Affairs Medical Center, Lexington, 40536, KY, USA.
  • Wang X; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, and Lexington Veterans Affairs Medical Center, Lexington, 40536, KY, USA.
  • Lusis AJ; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, and Lexington Veterans Affairs Medical Center, Lexington, 40536, KY, USA.
  • Arnold AP; Department of Microbiology, Immunology & Molecular Genetics, Human Genetics, College of Medicine, University of California, Los Angeles, 90095, CA, USA.
  • Reue K; Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 90095, CA, USA.
  • Thompson K; Human Genetics, University of California, Los Angeles, 90095, CA, USA.
  • Tso P; Department of Microbiology, Immunology & Molecular Genetics, Human Genetics, College of Medicine, University of California, Los Angeles, 90095, CA, USA.
  • Cassis LA; Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 90095, CA, USA.
Nat Commun ; 10(1): 2631, 2019 06 14.
Article em En | MEDLINE | ID: mdl-31201301
ABSTRACT
Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effects of sex chromosomes on circulating lipids and atherosclerosis are unknown. Here, we use mouse models to separate effects of sex chromosomes and hormones on atherosclerosis, circulating lipids and intestinal fat metabolism. We assess atherosclerosis in multiple models and experimental paradigms that distinguish effects of sex chromosomes, and male or female gonads. Pro-atherogenic lipids and atherosclerosis are greater in XX than XY mice, indicating a primary effect of sex chromosomes. Small intestine expression of enzymes involved in lipid absorption and chylomicron assembly are greater in XX male and female mice with higher intestinal lipids. Together, our results show that an XX sex chromosome complement promotes the bioavailability of dietary fat to accelerate atherosclerosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromossomo X / Aterosclerose / Metabolismo dos Lipídeos / Transtornos 46, XX do Desenvolvimento Sexual / Lipídeos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromossomo X / Aterosclerose / Metabolismo dos Lipídeos / Transtornos 46, XX do Desenvolvimento Sexual / Lipídeos Idioma: En Ano de publicação: 2019 Tipo de documento: Article