Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis.

Razori, María Valeria; Maidagan, Paula M; Ciriaci, Nadia; Andermatten, Romina B; Barosso, Ismael R; Martín, Pamela L; Basiglio, Cecilia L; Sánchez Pozzi, Enrique J; Ruiz, María Laura; Roma, Marcelo G

Razori, María Valeria; Maidagan, Paula M; Ciriaci, Nadia; Andermatten, Romina B; Barosso, Ismael R; Martín, Pamela L; Basiglio, Cecilia L; Sánchez Pozzi, Enrique J; Ruiz, María Laura; Roma, Marcelo G.

Afiliação

Razori MV; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Maidagan PM; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Ciriaci N; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Andermatten RB; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Barosso IR; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Martín PL; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Basiglio CL; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Sánchez Pozzi EJ; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Ruiz ML; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina.
Roma MG; Institute of Experimental Physiology (IFISE), Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, 2000 Rosario, Argentina. Electronic address: mroma@fbioyf.unr.edu.ar.

Biochem Pharmacol ; 168: 48-56, 2019 10.

Article em En | MEDLINE | ID: mdl-31202734

Assuntos

Colagogos e Coleréticos/uso terapêutico; Colestase/induzido quimicamente; Colestase/tratamento farmacológico; Lipopolissacarídeos/farmacologia; Ácido Ursodesoxicólico/uso terapêutico; Membro 11 da Subfamília B de Transportadores de Cassetes de Ligação de ATP/metabolismo; Transportadores de Cassetes de Ligação de ATP/metabolismo; Fosfatase Alcalina/sangue; Animais; Ácidos e Sais Biliares/metabolismo; Colagogos e Coleréticos/administração & dosagem; Colagogos e Coleréticos/farmacologia; Modelos Animais de Doenças; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Fígado/metabolismo; Masculino; Ratos; Ratos Wistar; Resultado do Tratamento; Ácido Ursodesoxicólico/administração & dosagem; Ácido Ursodesoxicólico/farmacologia

Palavras-chave

Bile acid export pump; Bile acids; Hepatocellular transporters; Lipopolysaccharide-induced cholestasis; Ursodeoxycholic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Ursodesoxicólico / Colagogos e Coleréticos / Lipopolissacarídeos / Colestase Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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