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Cytotoxic glycosides from the roots of Weigela x "Bristol Ruby".
Nguyen, Duc Hung; Mitaine-Offer, Anne-Claire; Maroso, Sveva; Papini, Anna-Maria; Paululat, Thomas; Bellaye, Pierre-Simon; Collin, Bertrand; Chambin, Odile; Lacaille-Dubois, Marie-Aleth.
Afiliação
  • Nguyen DH; PEPITE EA 4267, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Dijon, Cedex, France; Department of Biology, Thainguyen University of Education, Thainguyen University, 24000 Thainguyen, Viet Nam; Department of Pharmaceutical Technology
  • Mitaine-Offer AC; PEPITE EA 4267, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Dijon, Cedex, France. Electronic address: anne-claire.offer@u-bourgogne.fr.
  • Maroso S; Department of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.
  • Papini AM; Department of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.
  • Paululat T; OC-II, Naturwissenschaftlich-Technische Fakultät, Universität Siegen, D-57076 Siegen, Germany.
  • Bellaye PS; Plateforme d'Imagerie et de Radiothérapie Précliniques, Service de Médecine Nucléaire, Centre Georges-François Leclerc, BP77980, 21079 Dijon, Cedex, France.
  • Collin B; Plateforme d'Imagerie et de Radiothérapie Précliniques, ICMUB UMR CNRS 6302, Service de Médecine Nucléaire, Centre Georges-François Leclerc, BP77980, 21079 Dijon, Cedex, France.
  • Chambin O; Department of Pharmaceutical Technology, PAM UMR A 02.102, PCAV team, Université de Bourgogne Franche-Comté, Dijon, France.
  • Lacaille-Dubois MA; PEPITE EA 4267, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Dijon, Cedex, France.
Fitoterapia ; 137: 104242, 2019 Sep.
Article em En | MEDLINE | ID: mdl-31202889
ABSTRACT
Seven oleanane-type glycosides were extracted and isolated by various chromatographic methods from the roots of Weigela x "Bristol Ruby" (1-7), six previously undescribed (1-6) and a known one (7). Their structures were assigned by spectroscopic analysis mainly 2D NMR and mass spectrometry (ESIMS). Selected triterpenoid glycosides (1-3, 6, 7) displayed a good cytotoxic activity against a mouse colon cancer cell line CT26.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Caprifoliaceae / Glicosídeos / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Caprifoliaceae / Glicosídeos / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article