[Clinical Features and Therapeutic Efficacy in Adult Acute Lymphoblastic Leukemia with t (1; 19) (E2A-PBX1)].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 27(3): 637-640, 2019 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-31204910
ABSTRACT
OBJECTIVE:
To explore the clinical features and therapeutic efficacy in adult ALL patients with t (1; 19) (E2A-PBX1).METHODS:
The clinic data of 19 adult ALL patients with t (1; 19) (E2A-PBX1) in our hospital from Nov. 22, 2010 to Apr. 4, 2018 were collected. The clinical features,complete remission (CR) rate, overall survival (OS) rate and relapse-free survival (RFS) rate of patients received chemotherapy and chemotherapy+HSCT were analyzed.RESULTS:
In all the 19 patients, the median age was 24 (14-66), median WBC count was 16.47×109 (1.8-170.34)/L, median Hb level was 98 (65-176) g/L, median Plt count was 50 (15-254)×109/L. Pre B-ALL were 17 cases (89.5%), and common B-ALL were 2 cases (10.5%). Patients received the induction therapy, the overall CR rate was 94.7%, one course CR rate was 94.7%, 4 year OS rate was 47.1% and RFS rate was 43.3%. The OS rate and RFS rate of patients received transplantation were slightly higher than those of patients not received transplantation (OS 62.5% vs 36.7%) (P=0.188)ï¼RFS (62.5% vs 38.9%) (P=0.166).CONCLUSION:
Most adult ALL patients with t (1; 19) (E2A-PBX1) is Pre B-ALL by Immunophenotyping, as compared with the pediatric patients, the therapeutic efficacy for adult patients with t (1; 19) (E2A-PBX1) is worsen, therefore, stem cell transplantation is still acquired for better long term survival.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Fusão Oncogênica
/
Proteínas de Homeodomínio
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
Zh
Ano de publicação:
2019
Tipo de documento:
Article