A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells.
PLoS One
; 14(6): e0218567, 2019.
Article
em En
| MEDLINE
| ID: mdl-31211796
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the effect of adding xanthan gum to the diet of rats on the production of cytokines and pro-inflammatory factors and on tumor development in rats inoculated with Walker 256 tumor cells.METHODS:
Fifty-six rats were divided into 4 groups control diet (C), control diet with tumor (TC), xanthan gum diet (XG), xanthan gum diet with tumor (TXG).RESULTS:
The ingestion of xanthan gum promotes changes in cytokine content increasing IL-6 TNF-α and IL-10 in retroperitoneal adipose tissue compared to the control group; and increasing TNF-α in the mesenteric adipose tissue compared to the C and TXG groups. On the contrary, the addition of xanthan gum to the diet did not affect the development of Walker 256 tumors in rats.CONCLUSION:
The continuous use of xanthan gum triggered a pro-inflammatory response, promoting an increase in pro-inflammatory cytokines in the adipose tissue, but it did not have an effect on the tumor development in the animals inoculated with Walker 256 tumor cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
/
Dieta
/
Inflamação
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article