Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/ß-catenin signaling.

Lv, Min-Yi; Shi, Chuan-Jian; Pan, Fei-Fei; Shao, Jiang; Feng, Lu; Chen, Guoqin; Ou, Caiwen; Zhang, Jin-Fang; Fu, Wei-Ming

Lv, Min-Yi; Shi, Chuan-Jian; Pan, Fei-Fei; Shao, Jiang; Feng, Lu; Chen, Guoqin; Ou, Caiwen; Zhang, Jin-Fang; Fu, Wei-Ming.

Afiliação

Lv MY; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
Shi CJ; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
Pan FF; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
Shao J; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
Feng L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
Chen G; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
Ou C; Key Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Zhang JF; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Fu WM; Department of Orthopaedics and Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.

J Cell Biochem ; 120(10): 17273-17282, 2019 10.

Article em En | MEDLINE | ID: mdl-31218741

Assuntos

Carcinoma Hepatocelular/tratamento farmacológico; Cumarínicos/farmacologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Neoplasias Hepáticas/tratamento farmacológico; Proteínas Wnt/antagonistas & inibidores; Via de Sinalização Wnt/efeitos dos fármacos; beta Catenina/antagonistas & inibidores; Animais; Apoptose; Biomarcadores Tumorais/metabolismo; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Ciclo Celular; Movimento Celular; Proliferação de Células; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Camundongos; Camundongos Nus; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Wnt/ß-catenin; apoptosis; cell cycle; hepatocellular carcinoma; urolithin B

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Cumarínicos / Proteínas Wnt / Beta Catenina / Via de Sinalização Wnt / Neoplasias Hepáticas Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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