A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence.
Chem Commun (Camb)
; 55(60): 8860-8863, 2019 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-31219109
ABSTRACT
We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipóxia Celular
/
Complexos de Coordenação
/
Fluoresceínas
/
Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article