Preclinical and translational pharmacokinetics of a novel THIOMAB&#8482; antibody-antibiotic conjugate against <i>Staphylococcus aureus</i>.

Deng, Rong; Zhou, Chenguang; Li, Dongwei; Cai, Hao; Sukumaran, Siddharth; Carrasco-Triguero, Montserrat; Saad, Ola; Nazzal, Denise; Lowe, Christopher; Ramanujan, Saroja; Kamath, Amrita V

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus.

Deng, Rong; Zhou, Chenguang; Li, Dongwei; Cai, Hao; Sukumaran, Siddharth; Carrasco-Triguero, Montserrat; Saad, Ola; Nazzal, Denise; Lowe, Christopher; Ramanujan, Saroja; Kamath, Amrita V.

Afiliação

Deng R; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Zhou C; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Li D; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Cai H; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Sukumaran S; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Carrasco-Triguero M; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Saad O; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Nazzal D; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Lowe C; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Ramanujan S; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Kamath AV; a Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.

MAbs ; 11(6): 1162-1174, 2019.

Article em En | MEDLINE | ID: mdl-31219754

Assuntos

Anticorpos Antibacterianos; Anticorpos Monoclonais; Imunoconjugados; Imunoglobulina G; Rifamicinas; Staphylococcus aureus/imunologia; Animais; Anticorpos Antibacterianos/imunologia; Anticorpos Antibacterianos/farmacologia; Anticorpos Monoclonais/imunologia; Anticorpos Monoclonais/farmacocinética; Anticorpos Monoclonais/farmacologia; Imunoconjugados/imunologia; Imunoconjugados/farmacocinética; Imunoconjugados/farmacologia; Imunoglobulina G/imunologia; Imunoglobulina G/farmacologia; Macaca fascicularis; Masculino; Ratos; Ratos Sprague-Dawley; Rifamicinas/imunologia; Rifamicinas/farmacocinética; Rifamicinas/farmacologia

Palavras-chave

Pharmacokinetics; Staphylococcus aureus; THIOMAB™ antibody-antibiotic conjugate (TAC); allometric scaling; semi-mechanistic pharmacokinetic model; translation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rifamicinas / Staphylococcus aureus / Imunoglobulina G / Imunoconjugados / Anticorpos Antibacterianos / Anticorpos Monoclonais Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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