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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
Harris, Philip A; Marinis, Jill M; Lich, John D; Berger, Scott B; Chirala, Anirudh; Cox, Julie A; Eidam, Patrick M; Finger, Joshua N; Gough, Peter J; Jeong, Jae U; Kang, James; Kasparcova, Viera; Leister, Lara K; Mahajan, Mukesh K; Miller, George; Nagilla, Rakesh; Ouellette, Michael T; Reilly, Michael A; Rendina, Alan R; Rivera, Elizabeth J; Sun, Helen H; Thorpe, James H; Totoritis, Rachel D; Wang, Wei; Wu, Dongling; Zhang, Daohua; Bertin, John; Marquis, Robert W.
Afiliação
  • Harris PA; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Marinis JM; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Lich JD; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Berger SB; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Chirala A; S. Arthur Localio Laboratory and Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, United States.
  • Cox JA; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Eidam PM; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Finger JN; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Gough PJ; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Jeong JU; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Kang J; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Kasparcova V; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Leister LK; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Mahajan MK; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Miller G; S. Arthur Localio Laboratory and Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, United States.
  • Nagilla R; S. Arthur Localio Laboratory and Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, United States.
  • Ouellette MT; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Reilly MA; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Rendina AR; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Rivera EJ; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Sun HH; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Thorpe JH; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Totoritis RD; Medicinal Science & Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Wang W; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Wu D; S. Arthur Localio Laboratory and Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, United States.
  • Zhang D; S. Arthur Localio Laboratory and Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, United States.
  • Bertin J; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Marquis RW; Pattern Recognition Receptor DPU and Medicinal Science & Technology, GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
ACS Med Chem Lett ; 10(6): 857-862, 2019 Jun 13.
Article em En | MEDLINE | ID: mdl-31223438
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article