Mamey sapote fruit and carotenoid formulations derived thereof are dietary sources of vitamin A - A comparative randomized cross-over study.
Food Res Int
; 122: 340-347, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31229087
ABSTRACT
Mamey sapote is a fruit rich in specific keto-carotenoids, namely sapotexanthin and cryptocapsin. Their chemical structure suggests their provitamin A activity, although their absorption and conversion to vitamin A remained to be demonstrated in humans. Besides structure-related factors, the fruit matrix might also hamper absorption and conversion efficiency. Therefore, we monitored carotenoid and vitamin A levels in triacylglycerol-rich lipoprotein (TRL) fractions in plasma of human participants after consumption of fresh sapote and a carotenoid-rich "matrix-free" formulation derived thereof. A randomized 2-way cross-over study was conducted to compare the post-prandial bioavailability of 0.8â¯mg sapotexanthin and 1.2-1.5â¯mg cryptocapsin from the above-mentioned test meals. Seven blood samples were drawn over 9.5â¯h after test meal consumption. Carotenoids and retinoids were quantitated in TRL fractions using HPLC-DAD. Sapotexanthin was absorbed by all participants from all meals, being ca. 36% more bioavailable from the "matrix-free" formulation (AUCmedianâ¯=â¯73.4â¯nmolâh/L) than from the fresh fruit (AUCmedianâ¯=â¯54.0â¯nmolâh/L; pâ¯≤â¯0.001). Cryptocapsin was only absorbed by 4 of 13 participants. The appearance of retinyl esters was observed in all participants independent of the test meal. Although the fruit matrix hampered carotenoid in vivo-bioavailability from sapote, the fruit clearly represents a valuable source of vitamin A for humans.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina A
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Carotenoides
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Manilkara
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article