Fueling Melanocytes with ATP from Keratinocytes Accelerates Melanin Synthesis.
J Invest Dermatol
; 139(7): 1424-1426, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31230638
ABSTRACT
Melanocyte homoeostasis and their response to ultraviolet radiation (UVR) are mediated to a large extent by keratinocyte-derived factors, many of which have been well-characterized. Lee et al. describe novel effects of adenosine 5'-triphosphate (ATP), which is secreted by keratinocytes and can stimulate melanogenesis by melanocytes following UVA exposure. The investigators attribute the melanogenic effect of ATP to binding purinergic receptors type 2 X7 (P2X7), which are expressed on human melanocytes, leading to activation of the protein kinase C pathway. This report is the first to identify expression of specific purinergic receptors on human melanocytes, and it suggests ATP as a signaling molecule that stimulates pigmentation. Follow up on these results should clarify the physiological role of ATP in mediating the tanning response to solar UVR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Queratinócitos
/
Melaninas
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article