The role of CXCR3 and its ligands CXCL10 and CXCL11 in the pathogenesis of celiac disease.
Medicine (Baltimore)
; 98(25): e15949, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31232926
ABSTRACT
The chemokine receptor CXCR3 and its ligands CXCL10 and CXCL11 have been suggested to give rise to the most relevant chemokine axis able to facilitate the entrance of immune cells into inflamed tissues and be activated in different inflammatory disorders, such as celiac disease (CD).The aim of this study was to investigate the expression level of CXCR3, CXCL10, and CXCL11 genes in celiac patients compared to healthy controls. Both cohorts have been recruited from the Iranian population.In this case-control study, biopsy specimens were collected from 71 celiac patients (60.5% female) and 90 control subjects (57% female) during 2016. Total RNA was extracted and mRNA expression levels of CXCR3, CXCL10, and CXCL11 genes were investigated by SYBR green qPCR.Based on qPCR and relative quantification method, the mRNA expression levels of CXCR3, CXCL10, and CXCL11 were significantly higher in duodenal biopsies of celiac patients compared to healthy controls in the study population (Pâ=â.038, Pâ=â.021, and Pâ=â.012 respectively).The result of this study showed that CXCR3/CXCL10/CXCL11 signaling axis is overexpressed in the small intestinal mucosa of CD patients compared to controls. This finding might explain the specific enrollment of the main cell populations that infiltrate the epithelium.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença Celíaca
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Quimiocina CXCL10
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Quimiocina CXCL11
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Receptores CXCR3
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article