Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy.

Xu, Bingru; Zhu, Liyang; Chu, Jin; Ma, Zhanqiang; Fu, Qiang; Wei, Wei; Deng, Xueyang; Ma, Shiping

Xu, Bingru; Zhu, Liyang; Chu, Jin; Ma, Zhanqiang; Fu, Qiang; Wei, Wei; Deng, Xueyang; Ma, Shiping.

Afiliação

Xu B; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
Zhu L; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
Chu J; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
Ma Z; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
Fu Q; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
Wei W; School of Electronics and Information, Xi'an Polytechnic University, Xi'an, China. Electronic address: weiwei@xpu.edu.cn.
Deng X; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: dxy@cpu.edu.cn.
Ma S; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China; Qinba Traditional Chinese Medicine Resources Research and Development Center, AnKang University, AnKang 725000, China. Electronic address: spma@cpu.edu.cn.

Behav Brain Res ; 372: 112007, 2019 10 17.

Article em En | MEDLINE | ID: mdl-31238056

Assuntos

Disfunção Cognitiva/tratamento farmacológico; Ataque Isquêmico Transitório/tratamento farmacológico; Umbeliferonas/farmacologia; Animais; Apoptose/efeitos dos fármacos; Autofagia/efeitos dos fármacos; Isquemia Encefálica/tratamento farmacológico; Disfunção Cognitiva/metabolismo; Dinaminas/análise; Ataque Isquêmico Transitório/metabolismo; Masculino; Malondialdeído/análise; Camundongos; Camundongos Endogâmicos ICR; Mitocôndrias/metabolismo; Mitofagia/efeitos dos fármacos; Fator 2 Relacionado a NF-E2/análise; Espécies Reativas de Oxigênio/metabolismo; Traumatismo por Reperfusão/metabolismo; Superóxido Dismutase/análise; Umbeliferonas/metabolismo

Palavras-chave

Cerebral ischaemia; Esculetin; Mitochondrial fragmentation; Mitophagy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Umbeliferonas / Ataque Isquêmico Transitório / Disfunção Cognitiva Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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