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Renal-Limited Thrombotic Microangiopathy due to Bevacizumab Therapy for Metastatic Colorectal Cancer: A Case Report.
Toriu, Naoya; Sekine, Akinari; Mizuno, Hiroki; Hasegawa, Eiko; Yamanouchi, Masayuki; Hiramatsu, Rikako; Hayami, Noriko; Hoshino, Junichi; Kawada, Masahiro; Suwabe, Tatsuya; Sumida, Keiichi; Sawa, Naoki; Takaichi, Kenmei; Ohashi, Kenichi; Fujii, Takeshi; Matoba, Shuichiro; Ubara, Yoshifumi.
Afiliação
  • Toriu N; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Sekine A; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Mizuno H; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Hasegawa E; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Yamanouchi M; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Hiramatsu R; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Hayami N; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Hoshino J; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Kawada M; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Suwabe T; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Sumida K; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Sawa N; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Takaichi K; Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Ohashi K; Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
  • Fujii T; Department of Pathology, Toranomon Hospital, Tokyo, Japan.
  • Matoba S; Department of Pathology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.
  • Ubara Y; Department of Pathology, Toranomon Hospital, Tokyo, Japan.
Case Rep Oncol ; 12(2): 391-400, 2019.
Article em En | MEDLINE | ID: mdl-31244641
ABSTRACT
An 88-year-old Japanese man received bevacizumab for colorectal cancer with liver and peritoneal metastasis, during which nephrotic range proteinuria occurred (7.66 g/day). Renal biopsy showed endothelial damage with subendothelial swelling and a double contour of the glomerular basement membrane, which indicated a diagnosis of thrombotic microangiopathy (TMA). After bevacizumab was stopped, proteinuria decreased to 1 g/day. During the clinical course, this patient had no extrarenal manifestations. This case suggests that renal injury induced by bevacizumab is characterized by nephrotic range proteinuria and histological TMA, and is a renal-limited condition that differs from systemic TMA related to thrombotic thrombocytopenic purpura.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article