Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells.

Das, Momita; Kandimalla, Raghuram; Gogoi, Bhaskarjyoti; Dutta, Krishna Nayani; Choudhury, Paramita; Devi, Rajlakshmi; Dutta, Partha Pratim; Talukdar, Narayan Chandra; Samanta, Suman Kumar

Das, Momita; Kandimalla, Raghuram; Gogoi, Bhaskarjyoti; Dutta, Krishna Nayani; Choudhury, Paramita; Devi, Rajlakshmi; Dutta, Partha Pratim; Talukdar, Narayan Chandra; Samanta, Suman Kumar.

Afiliação

Das M; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Kandimalla R; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Gogoi B; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Dutta KN; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Choudhury P; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Devi R; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Dutta PP; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Talukdar NC; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India. Electronic address: nct@iasst.gov.in.
Samanta SK; Drug Discovery Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India. Electronic address: skshamanta@iasst.gov.in.

Pharmacol Res ; 146: 104330, 2019 08.

Article em En | MEDLINE | ID: mdl-31251988

Assuntos

Neoplasias da Mama/tratamento farmacológico; Carbazóis/farmacologia; Neoplasias Mamárias Animais/tratamento farmacológico; Células-Tronco Neoplásicas/efeitos dos fármacos; Compostos Fitoquímicos/farmacologia; Carga Tumoral/efeitos dos fármacos; Animais; Apoptose/efeitos dos fármacos; Mama/efeitos dos fármacos; Mama/metabolismo; Mama/patologia; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Dieta; Progressão da Doença; Feminino; Fase G1/efeitos dos fármacos; Humanos; Células MCF-7; Neoplasias Mamárias Animais/metabolismo; Neoplasias Mamárias Animais/patologia; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Ratos; Fase de Repouso do Ciclo Celular/efeitos dos fármacos

Palavras-chave

Breast cancer stem cells (bCSC); In vivo; Mahanine; Murraya koenigii; N-methyl-N-nitrosourea (MNU)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias da Mama / Carbazóis / Neoplasias Mamárias Animais / Carga Tumoral / Compostos Fitoquímicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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