Tau Aggregation Correlates with Amyloid Deposition in Both Mild Cognitive Impairment and Alzheimer's Disease Subjects.
J Alzheimers Dis
; 70(2): 455-465, 2019.
Article
em En
| MEDLINE
| ID: mdl-31256120
ABSTRACT
BACKGROUND:
Amyloid plaque and tau-containing neurofibrillary tangles are important features of Alzheimer's disease (AD). However, the relationship between these processes is still debated.OBJECTIVE:
We aimed to investigate local and distant relationships between tau and amyloid deposition in the cortex in mild cognitive impairment (MCI) and AD using PET imaging.METHODS:
Seventy-nine subjects (51 controls, 13 amyloid-positive MCI subjects, and 15 amyloid positive AD subjects) underwent MRI and 18F-flutemetamol PET. All MCI/AD subjects and 8 healthy controls as well as 33 healthy control subjects from the ADNI dataset also had 18F-AV1451 PET. Regional and distant correlations were examined after sampling target-to-cerebellar ratio images. Biological parametric mapping was used to evaluate voxel level correlations locally.RESULTS:
We found multiple clusters of voxels with highly significant positive correlations throughout the association cortex in both MCI and AD subjects.CONCLUSION:
The multiple clusters of positive correlations indicate that tau and amyloid may interact locally and be involved in disease progression. Our findings suggest that targeting both pathologies may be required.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Proteínas tau
/
Placa Amiloide
/
Doença de Alzheimer
/
Disfunção Cognitiva
/
Agregados Proteicos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article