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Synergistic photothermal/photodynamic suppression of prostatic carcinoma by targeted biodegradable MnO2 nanosheets.
Zeng, Dewang; Wang, Lei; Tian, Lu; Zhao, Shili; Zhang, Xianfeng; Li, Hongyan.
Afiliação
  • Zeng D; a Department of Nephrology , Huadu District People's Hospital of Guangzhou, Southern Medical University , Guangzhou , China.
  • Wang L; b Guizhou Population and Family Planning Science Research and Technology Guidance Institute , Guiyang , China.
  • Tian L; a Department of Nephrology , Huadu District People's Hospital of Guangzhou, Southern Medical University , Guangzhou , China.
  • Zhao S; a Department of Nephrology , Huadu District People's Hospital of Guangzhou, Southern Medical University , Guangzhou , China.
  • Zhang X; c Department of Gastroenterology , Huadu District People's Hospital of Guangzhou, Southern Medical University , Guangzhou , China.
  • Li H; a Department of Nephrology , Huadu District People's Hospital of Guangzhou, Southern Medical University , Guangzhou , China.
Drug Deliv ; 26(1): 661-672, 2019 Dec.
Article em En | MEDLINE | ID: mdl-31257941
ABSTRACT
The biodegradability and clearance of metal-based nanomaterials have been questioned worldwide, which have greatly limited their clinical translation. Herein, ultrathin manganese dioxide (MnO2) nanosheets with broad near-infrared (NIR) absorption and pH-dependent degradation properties were prepared. After being modified with polyethylene glycol-cyclic arginine-glycineaspartic acid tripeptide (PEG-cRGD), the MnO2 nanosheets were then used as photothermal agent and nanocarrier to encapsulate chlorin e6 (Ce6) for targeted photothermal (PTT) and photodynamic (PDT) of cancer. As expected, the MnO2-PEG-cRGD nanosheets show high Ce6 loading capacity (351 mg/g), superb photothermal conversion performance (37.2%) and excellent colloidal stability. These nanosheets also exhibit pH-dependent and NIR-induced Ce6 release. Furthermore, the MnO2 nanosheets can be degraded by reacting with hydrogen peroxide in the acidic microenvironment, which are able to elevate the oxygen concentration in situ and thus reverses the tumor hypoxia. Thanks to these favorable properties and the cRGD-mediated tumor-targeted ability, the fabricated MnO2-PEG-cRGD/Ce6 nanocomposites can be effectively up taken by alpha-v beta-3 (αvß3) integrin over-expressed prostatic carcinoma PC3 cells and achieve favorable therapeutic outcomes under a single 660 nm NIR laser, which is also verified by in vitro studies. The biodegradable MnO2-PEG-cRGD/Ce6 nanosheets developed in this work can be a promising nanoplatform for synergetic PTT/PDT cancer therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxidos / Neoplasias da Próstata / Carcinoma / Compostos de Manganês / Nanoestruturas / Plásticos Biodegradáveis Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxidos / Neoplasias da Próstata / Carcinoma / Compostos de Manganês / Nanoestruturas / Plásticos Biodegradáveis Idioma: En Ano de publicação: 2019 Tipo de documento: Article