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Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging.
Yanagi, Shota; Sugai, Tomoya; Noguchi, Takuma; Kawakami, Masato; Sasaki, Makoto; Niwa, Shinsuke; Sugimoto, Asako; Fuwa, Haruhiko.
Afiliação
  • Yanagi S; Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
  • Sugai T; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. hfuwa.50m@g.chuo-u.ac.jp.
  • Noguchi T; Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
  • Kawakami M; Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
  • Sasaki M; Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
  • Niwa S; Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, 6-3 Aramaki Aoba, Aoba-ku, Sendai, Miyagi 980-0845, Japan.
  • Sugimoto A; Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
  • Fuwa H; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. hfuwa.50m@g.chuo-u.ac.jp.
Org Biomol Chem ; 17(28): 6771-6776, 2019 07 17.
Article em En | MEDLINE | ID: mdl-31259993
ABSTRACT
Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Macrolídeos / Imagem Óptica / Fluorescência / Corantes Fluorescentes Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Macrolídeos / Imagem Óptica / Fluorescência / Corantes Fluorescentes Idioma: En Ano de publicação: 2019 Tipo de documento: Article