Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.
Nat Immunol
; 20(8): 1004-1011, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31263280
ABSTRACT
Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
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Linfócitos
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Proteínas do Envelope Viral
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Muromegalovirus
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Memória Imunológica
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Fígado
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article