Complexes of thrombin with secreted platelet proteins.
Biochem Biophys Res Commun
; 151(1): 9-15, 1988 Feb 29.
Article
em En
| MEDLINE
| ID: mdl-3126741
ABSTRACT
A labeled 77-kDa complex formed when 125I-thrombin was added to platelet suspensions or to the supernatant solution of ionophore-activated platelets. Prostacyclin inhibited complex formation with whole platelets but not with the supernatant solution of ionophore-activated platelets. This is evidence that the complex formed with a factor secreted from activated platelets. Smaller complexes of 70 and 58 kDa formed between labeled thrombin and lysed platelets. The 77-kDa complex was necessary for the formation of a thrombin-thrombospondin complex.
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Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Proteínas Sanguíneas
/
Trombina
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article