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CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease.
Kacher, Radhia; Lamazière, Antonin; Heck, Nicolas; Kappes, Vincent; Mounier, Coline; Despres, Gaëtan; Dembitskaya, Yulia; Perrin, Elodie; Christaller, Wilhelm; Sasidharan Nair, Satish; Messent, Valérie; Cartier, Nathalie; Vanhoutte, Peter; Venance, Laurent; Saudou, Frédéric; Néri, Christian; Caboche, Jocelyne; Betuing, Sandrine.
Afiliação
  • Kacher R; Neuroscience Paris Seine, Institut de Biologie Paris-Seine, CNRS UMR 8246/INSERM U1130., Sorbonne Université, Paris, France.
  • Lamazière A; LBM, CNRS UMR7203/INSERM U1157, Sorbonne Université, Faculté de Médecine, AP-HP, Hôpital Saint Antoine, Département PM2, Paris, France.
  • Heck N; Neuroscience Paris Seine, Institut de Biologie Paris-Seine, CNRS UMR 8246/INSERM U1130., Sorbonne Université, Paris, France.
  • Kappes V; Neuroscience Paris Seine, Institut de Biologie Paris-Seine, CNRS UMR 8246/INSERM U1130., Sorbonne Université, Paris, France.
  • Mounier C; Neuroscience Paris Seine, Institut de Biologie Paris-Seine, CNRS UMR 8246/INSERM U1130., Sorbonne Université, Paris, France.
  • Despres G; LBM, CNRS UMR7203/INSERM U1157, Sorbonne Université, Faculté de Médecine, AP-HP, Hôpital Saint Antoine, Département PM2, Paris, France.
  • Dembitskaya Y; Center for Interdisciplinary Research in Biology, College de France, CNRS UMR7241/INSERM U1050, MemoLife Labex Paris, France.
  • Perrin E; Center for Interdisciplinary Research in Biology, College de France, CNRS UMR7241/INSERM U1050, MemoLife Labex Paris, France.
  • Christaller W; Université Grenoble Alpes, Grenoble Institut des Neurosciences, INSERM U1216, CHU Grenoble Alpes, 38000 Grenoble, France.
  • Sasidharan Nair S; Sorbonne Université, Centre National de la Recherche Scientifique, Research Unit Biology of Adaptation and Aging (B2A), Team Compensation in Neurodegenerative and Aging (Brain-C), F-75252, Paris, France.
  • Messent V; Neuroplasticity of Reproductive Behaviors, Sorbonne Université, CNRS, INSERM, Neurosciences Paris Seine, Institut de Biologie Paris Seine, Faculté des Sciences et Ingénierie, INSERM/UMR-S 1130, CNRS/UMR 8246, 75005 Paris, France.
  • Cartier N; Biotherapies for neurodegenerative diseases, Institut du Cerveau et de la Moelle (ICM) INSERM Sorbonne Université, Paris, France.
  • Vanhoutte P; Neuroscience Paris Seine, Institut de Biologie Paris-Seine, CNRS UMR 8246/INSERM U1130., Sorbonne Université, Paris, France.
  • Venance L; Center for Interdisciplinary Research in Biology, College de France, CNRS UMR7241/INSERM U1050, MemoLife Labex Paris, France.
  • Saudou F; Université Grenoble Alpes, Grenoble Institut des Neurosciences, INSERM U1216, CHU Grenoble Alpes, 38000 Grenoble, France.
  • Néri C; Sorbonne Université, Centre National de la Recherche Scientifique, Research Unit Biology of Adaptation and Aging (B2A), Team Compensation in Neurodegenerative and Aging (Brain-C), F-75252, Paris, France.
  • Caboche J; Neuroscience Paris Seine, Institut de Biologie Paris-Seine, CNRS UMR 8246/INSERM U1130., Sorbonne Université, Paris, France.
  • Betuing S; Neuroscience Paris Seine, Institut de Biologie Paris-Seine, CNRS UMR 8246/INSERM U1130., Sorbonne Université, Paris, France.
Brain ; 142(8): 2432-2450, 2019 08 01.
Article em En | MEDLINE | ID: mdl-31286142
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Terapia Genética / Colesterol / Doença de Huntington / Fármacos Neuroprotetores / Colesterol 24-Hidroxilase / Vetores Genéticos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Terapia Genética / Colesterol / Doença de Huntington / Fármacos Neuroprotetores / Colesterol 24-Hidroxilase / Vetores Genéticos Idioma: En Ano de publicação: 2019 Tipo de documento: Article