Major infections after bypass surgery and stenting for multivessel coronary disease in the randomised SYNTAX trial.
EuroIntervention
; 15(17): 1520-1526, 2020 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-31289019
ABSTRACT
AIMS:
Incidence, associated risk factors and impact on mortality of infections after bypass surgery (CABG) and stenting (PCI) for multivessel coronary disease (MVD) have never been reported in a large randomised trial. The aim of the present study was to evaluate, in patients with MVD, the prevalence of major infections after PCI and CABG and to assess their impact on mortality. METHODS ANDRESULTS:
The SYNTAX trial randomised 1,800 MVD patients to either CABG or PCI. Patients were followed up to five years. The primary endpoint of this post hoc analysis was the occurrence of major infection. At five years of follow-up, the primary endpoint had occurred in 142 (15.8%) patients in the CABG arm and 44 (4.9%) patients in the PCI arm (≤60 days HR - 7.9, 95% CI 4.7 to 13.1; p<0.001) (>60 days - HR 0.79, 95% CI 0.44 to 1.44; p=0.45). Major infections were independently associated with a higher risk of all-cause mortality at five years (adjusted HR 2.6, 95% CI 1.8 to 3.8, p<0.001).CONCLUSIONS:
CABG is associated with a higher incidence of post-procedure major infections compared to PCI. Major infections are independently associated with all-cause mortality.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Infecção da Ferida Cirúrgica
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Doença da Artéria Coronariana
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Ponte de Artéria Coronária
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Intervenção Coronária Percutânea
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article