Health implication of vitamin D on the cardiovascular and the renal system.
Arch Physiol Biochem
; 127(3): 195-209, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-31291127
ABSTRACT
Vitamin D regulates the calcium and phosphorus balance in the body. The activated form of vitamin D (1 α,25-dihydroxyvitamin D) binds to vitamin D receptor which regulates genes that control cell proliferation, differentiation and apoptosis. In the cardiovascular system, the vitamin D receptor is present in cardiomyocytes and the arterial wall. A clear correlation between vitamin D level and cardiovascular diseases is established. Vitamin D deficiency affects the renin-angiotensin system leading to ventricular hypertrophy and eventually to stroke. While clinical trials highlighted the positive effects of vitamin D supplements on cardiovascular disease these still need to be confirmed. This review outlines the association between vitamin D and cardiovascular and renal disease summarising the experimental data of selective cardiovascular disorders.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Sistema Cardiovascular
/
Saúde
/
Rim
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article