Biomarkers in systemic sclerosis-associated interstitial lung disease: review of the literature.
Rheumatology (Oxford)
; 58(9): 1534-1546, 2019 09 01.
Article
em En
| MEDLINE
| ID: mdl-31292645
ABSTRACT
SSc is a rare disease of unknown origin associated with multiple organ involvement. One of the major complications that drives the mortality of SSc patients is interstitial lung disease. The course of SSc-interstitial lung disease progression has a wide spectrum. Since the treatment is based on aggressive immunosuppression it should not be given to stable or non-progressing disease. The correct identification of disease with high risk of progression remains a challenge for early therapeutic intervention, and biomarkers remain urgently needed. In fact, eight categories of biomarkers have been identified and classified according to the different biological pathways involved. The purpose of this article is to describe the main biomarkers thought to be of interest with clinical value in the diagnosis and prognosis of SSc-interstitial lung disease.
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Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
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Biomarcadores
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Doenças Pulmonares Intersticiais
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article