Dynamically enhancing plaque targeting via a positive feedback loop using multifunctional biomimetic nanoparticles for plaque regression.

Jiang, Cuiping; Qi, Zitong; He, Wanhua; Li, Zhuoting; Tang, Yuqi; Wang, Yunbo; Huang, Yilei; Zang, Haojing; Yang, Hu; Liu, Jianping

Jiang, Cuiping; Qi, Zitong; He, Wanhua; Li, Zhuoting; Tang, Yuqi; Wang, Yunbo; Huang, Yilei; Zang, Haojing; Yang, Hu; Liu, Jianping.

Afiliação

Jiang C; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Qi Z; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
He W; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Li Z; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Tang Y; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Wang Y; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Huang Y; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Zang H; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Yang H; Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, United States; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, United States; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, Unit
Liu J; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China. Electronic address: jianpingliu1293@163.com.

J Control Release ; 308: 71-85, 2019 08 28.

Article em En | MEDLINE | ID: mdl-31295543

Assuntos

Materiais Biomiméticos/administração & dosagem; Retroalimentação Fisiológica/fisiologia; Nanopartículas; Placa Aterosclerótica/prevenção & controle; Trifosfato de Adenosina; Animais; Apolipoproteínas E/genética; Antígenos CD36/metabolismo; Lipoproteínas HDL/metabolismo; Macrófagos/metabolismo; Masculino; Camundongos; Camundongos Knockout; Células RAW 264.7; RNA Interferente Pequeno/administração & dosagem

Palavras-chave

Atherosclerosis; Dual-targeting; Nanocarrier; Plaque regression; Plaque targeting; Positive feedback loop

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retroalimentação Fisiológica / Materiais Biomiméticos / Nanopartículas / Placa Aterosclerótica Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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