A novel core-shell nanofiber drug delivery system intended for the synergistic treatment of melanoma.
Eur J Pharm Sci
; 137: 105002, 2019 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-31302215
ABSTRACT
Here, we introduce core-shell nanofibers based on chitosan (CS)-loaded poly (ε-caprolactone) (PCL) shell and 5-fluorouracil (5-FU)-loaded Poly(N-vinyl-2-pyrrolidone) (PVP) core for synergistic therapy of melanoma skin cancer. The yielded nanofibers exhibited an average diameter of 503â¯nm with high drug-encapsulating efficiency and good mechanical properties. Moreover, the burst release of 5-FU significantly inhibited melanoma skin cancer cells (B16F10 cells), and the sustained release of CS exhibited "remedying effects" on normal skin cells (L929 cells) after suffering adverse effects from 5-FU treatment. For the B16F10 cells, the early apoptosis cells increased from 0.8% to 62.2% after being treated with blended films loaded with 5-FU (2â¯wt%) for 24â¯h; for the L929 cells, the vital cells increased from 68.9% to 77.0%, and the early apoptosis of stage cells decreased from 12.3% to 10.9% after being treated with blended films with CS (8â¯wt%) for 24â¯h. In conclusion, the results introduced in this work can be a promising strategy for cancer treatment and possesses synergism potential to broaden an avenue for chemotherapeutic therapy with minimum adverse effects on normal cells.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Poliésteres
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Povidona
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Sistemas de Liberação de Medicamentos
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Quitosana
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Nanofibras
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Fluoruracila
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Antineoplásicos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article