Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors.
Medchemcomm
; 10(6): 970-973, 2019 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-31303995
ABSTRACT
A new class of indole derivatives (3) have been identified as potent RSV fusion inhibitors. SAR exploration revealed that 5-Cl and the sulfonyl side chain of the indole scaffold are crucial for anti-RSV activity. Further optimization led to the discovery of a cyclic sulfone (8i) with 2 nM anti-RSV activity and a much improved PK profile compared to the non-cyclic sulfone counterpart.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
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Article