Flavonols and 4-thioflavonols as potential acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, structure-activity relationship and molecular docking studies.

Mughal, Ehsan Ullah; Sadiq, Amina; Ashraf, Jamshaid; Zafar, Muhammad Naveed; Sumrra, Sajjad Hussain; Tariq, Rubina; Mumtaz, Amara; Javid, Asif; Khan, Bilal Ahmad; Ali, Anser; Javed, Chaudhary Omer

Mughal, Ehsan Ullah; Sadiq, Amina; Ashraf, Jamshaid; Zafar, Muhammad Naveed; Sumrra, Sajjad Hussain; Tariq, Rubina; Mumtaz, Amara; Javid, Asif; Khan, Bilal Ahmad; Ali, Anser; Javed, Chaudhary Omer.

Afiliação

Mughal EU; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan. Electronic address: ehsan.ullah@uog.edu.pk.
Sadiq A; Department of Chemistry, Govt. College Women University, Sialkot 51300, Pakistan. Electronic address: amina.sadiq@gcwus.edu.pk.
Ashraf J; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Zafar MN; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Sumrra SH; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Tariq R; Department of Chemistry, Govt. College Women University, Sialkot 51300, Pakistan.
Mumtaz A; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus 22060, Pakistan.
Javid A; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Khan BA; Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Ali A; Department of Zoology, Mirpur University of Science and Technology, Mirpur 10250, Pakistan.
Javed CO; Department of Chemistry, Govt. College Women University, Sialkot 51300, Pakistan.

Bioorg Chem ; 91: 103124, 2019 10.

Article em En | MEDLINE | ID: mdl-31319297

Assuntos

Acetilcolinesterase/metabolismo; Butirilcolinesterase/metabolismo; Inibidores da Colinesterase/química; Flavonóis/química; Acetilcolinesterase/química; Butirilcolinesterase/química; Domínio Catalítico; Inibidores da Colinesterase/síntese química; Inibidores da Colinesterase/metabolismo; Flavonóis/síntese química; Flavonóis/metabolismo; Humanos; Simulação de Acoplamento Molecular; Estrutura Molecular; Ligação Proteica; Relação Estrutura-Atividade

Palavras-chave

3-hydroxyflavones; 4-thioflavonols; AChE/BChE inhibitors; Cholinesterases; Flavonoids; Flavonols; Molecular docking studies; Sulfur compounds

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase / Inibidores da Colinesterase / Flavonóis Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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