Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome.

Hargreaves, Patrick; Daoudlarian, Douglas; Theron, Michel; Kolb, Fabrice A; Manchester Young, Marianne; Reis, Bernhard; Tiaden, Andre; Bannert, Bettina; Kyburz, Diego; Manigold, Tobias

Hargreaves, Patrick; Daoudlarian, Douglas; Theron, Michel; Kolb, Fabrice A; Manchester Young, Marianne; Reis, Bernhard; Tiaden, Andre; Bannert, Bettina; Kyburz, Diego; Manigold, Tobias.

Afiliação

Hargreaves P; Department of Rheumatology, University Hospital Basel, Basel, Switzerland.
Daoudlarian D; Department of Rheumatology, University Hospital Basel, Basel, Switzerland.
Theron M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Kolb FA; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Manchester Young M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Reis B; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Tiaden A; Department of Rheumatology, University Hospital Basel, Basel, Switzerland.
Bannert B; Department of Rheumatology, University Hospital Basel, Basel, Switzerland.
Kyburz D; Department of Rheumatology, University Hospital Basel, Basel, Switzerland.
Manigold T; Department of Rheumatology, University Hospital Basel, Basel, Switzerland. Tobias.manigold@usb.ch.

Arthritis Res Ther ; 21(1): 175, 2019 07 18.

Article em En | MEDLINE | ID: mdl-31319889

Assuntos

Catepsinas/antagonistas & inibidores; Inibidores de Cisteína Proteinase/farmacologia; Pirazóis/farmacologia; Pirrolidinas/farmacologia; Saliva/imunologia; Síndrome de Sjogren/imunologia; Lágrimas/imunologia; Adulto; Idoso; Autoantígenos/imunologia; Autoantígenos/metabolismo; Catepsinas/imunologia; Catepsinas/metabolismo; Proliferação de Células/efeitos dos fármacos; Citocinas/imunologia; Citocinas/metabolismo; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Monócitos/efeitos dos fármacos; Monócitos/imunologia; Monócitos/metabolismo; Ribonucleoproteínas/imunologia; Ribonucleoproteínas/metabolismo; Saliva/enzimologia; Síndrome de Sjogren/sangue; Síndrome de Sjogren/enzimologia; Linfócitos T/efeitos dos fármacos; Linfócitos T/imunologia; Linfócitos T/metabolismo; Lágrimas/enzimologia; Antígeno SS-B

Palavras-chave

Cathepsin S; Primary Sjögren syndrome; RO5459072; T cell responses; Tear fluid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Pirrolidinas / Saliva / Lágrimas / Síndrome de Sjogren / Catepsinas / Inibidores de Cisteína Proteinase Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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