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NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance.
Li, Xiaoguang; Liu, Zhida; Zhang, Anli; Han, Chuanhui; Shen, Aijun; Jiang, Lingxiang; Boothman, David A; Qiao, Jian; Wang, Yang; Huang, Xiumei; Fu, Yang-Xin.
Afiliação
  • Li X; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
  • Liu Z; School of Public Health, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
  • Zhang A; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
  • Han C; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
  • Shen A; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
  • Jiang L; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
  • Boothman DA; Department of Radiation Oncology, Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46022, USA.
  • Qiao J; Department of Biochemistry and Molecular Biology, Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Wang Y; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
  • Huang X; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
  • Fu YX; Department of Radiation Oncology, Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46022, USA. xiuhuang@iu.edu.
Nat Commun ; 10(1): 3251, 2019 07 19.
Article em En | MEDLINE | ID: mdl-31324798
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Naftoquinonas / NAD(P)H Desidrogenase (Quinona) / Ensaios Antitumorais Modelo de Xenoenxerto / Neoplasias Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Naftoquinonas / NAD(P)H Desidrogenase (Quinona) / Ensaios Antitumorais Modelo de Xenoenxerto / Neoplasias Idioma: En Ano de publicação: 2019 Tipo de documento: Article