Carbon 11-choline positron emission tomography/computed tomography and palliative local therapy for castration-resistant prostate cancer.
Int Urol Nephrol
; 51(10): 1763-1769, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31325132
ABSTRACT
PURPOSE:
Carbon 11-choline positron emission tomography/computed tomography (11C-choline PET/CT) and subsequent local therapy for oligometastatic prostate cancer have been reported to be effective, but their effectiveness in castration-resistant prostate cancer (CRPC) remains unclear. Here, we evaluated the findings of 11C-choline PET/CT in CRPC patients and the efficacy of local treatments in correspondence of the pathologic choline uptake.METHODS:
We collected 12 cases of CRPC patients who underwent 11C-choline PET/CT between 2014 and 2016. The outcomes assessed included age, the prostate-specific antigen (PSA) value, the findings of 11C-choline PET/CT, the subsequent treatments, the PSA response following the treatments, and the progression-free survival (PFS).RESULTS:
Seven of 12 cases (median PSA, 3.29 ng/mL) had local prostate cancer and/or one or two metastatic lesions detected by the choline PET/CT. These localized lesions were treated with radiotherapy or lymphadenectomy. PSA decreased in all the seven cases and median PSA response was 86% (range, 23-100%). Median PFS was 8.5 months (range, 2.8-25.3 months). The other five cases (median PSA, 7.41 ng/mL) had multiple metastases and systemic therapies were continued in those cases.CONCLUSIONS:
11C-choline PET/CT and the correspondent local treatments may play an important role in the treatment sequence of CRPC in selected patients.Palavras-chave
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Assunto principal:
Cuidados Paliativos
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Radioisótopos de Carbono
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Colina
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Neoplasias de Próstata Resistentes à Castração
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article