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Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders.
Su, Shang; Yang, Zimo; Gao, Hongying; Yang, Haiyan; Zhu, Songbiao; An, Zixuan; Wang, Juanjuan; Li, Qing; Chandarlapaty, Sarat; Deng, Haiteng; Wu, Wei; Rao, Yu.
Afiliação
  • Su S; MOE Key Laboratory of Protein Sciences, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
  • Yang Z; MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Tsinghua University , Beijing 100084 , P. R. China.
  • Gao H; MOE Key Laboratory of Protein Sciences, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
  • Yang H; MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Tsinghua University , Beijing 100084 , P. R. China.
  • Zhu S; MOE Key Laboratory of Protein Sciences, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
  • An Z; MOE Key Laboratory of Bioinformatics, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
  • Wang J; MOE Key Laboratory of Protein Sciences, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
  • Li Q; MOE Key Laboratory of Protein Sciences, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
  • Chandarlapaty S; Human Oncology and Pathogenesis Program , Memorial Sloan Kettering Cancer Center (MSKCC) , New York , New York 10065 , United States.
  • Deng H; Human Oncology and Pathogenesis Program , Memorial Sloan Kettering Cancer Center (MSKCC) , New York , New York 10065 , United States.
  • Wu W; MOE Key Laboratory of Bioinformatics, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
  • Rao Y; MOE Key Laboratory of Protein Sciences, School of Life Sciences , Tsinghua University , Beijing 100084 , P. R. China.
J Med Chem ; 62(16): 7575-7582, 2019 08 22.
Article em En | MEDLINE | ID: mdl-31330105
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Talidomida / Quinase 6 Dependente de Ciclina / Bibliotecas de Moléculas Pequenas Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Talidomida / Quinase 6 Dependente de Ciclina / Bibliotecas de Moléculas Pequenas Idioma: En Ano de publicação: 2019 Tipo de documento: Article