PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating ß-Catenin<sup>Y654</sup>.

Gao, Chenxi; Chen, Guangming; Zhang, Dennis Han; Zhang, Judy; Kuan, Shih-Fan; Hu, Wenhuo; Esni, Farzad; Gao, Xuan; Guan, Jun-Lin; Chu, Edward; Hu, Jing

PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating ß-Catenin^Y654.

Gao, Chenxi; Chen, Guangming; Zhang, Dennis Han; Zhang, Judy; Kuan, Shih-Fan; Hu, Wenhuo; Esni, Farzad; Gao, Xuan; Guan, Jun-Lin; Chu, Edward; Hu, Jing.

Afiliação

Gao C; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; UPMC, Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Chen G; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; UPMC, Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Zhang DH; Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Zhang J; Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kuan SF; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Hu W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Esni F; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Gao X; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; UPMC, Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Guan JL; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Chu E; UPMC, Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Hu J; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; UPMC, Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: jih25@pitt.edu.

Cell Mol Gastroenterol Hepatol ; 8(4): 561-578, 2019.

Article em En | MEDLINE | ID: mdl-31330317

Assuntos

Carcinoma de Células Acinares/metabolismo; Carcinoma Ductal Pancreático/metabolismo; Quinase 2 de Adesão Focal/metabolismo; Neoplasias Pancreáticas/metabolismo; Lesões Pré-Cancerosas/metabolismo; beta Catenina/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Carcinoma in Situ/genética; Carcinoma in Situ/metabolismo; Carcinoma in Situ/patologia; Carcinoma de Células Acinares/genética; Carcinoma de Células Acinares/patologia; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/patologia; Proteínas de Ciclo Celular/metabolismo; Reprogramação Celular/fisiologia; Modelos Animais de Doenças; Feminino; Quinase 2 de Adesão Focal/genética; Masculino; Metaplasia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Nus; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patologia; Fosforilação; Lesões Pré-Cancerosas/genética; Lesões Pré-Cancerosas/patologia; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Via de Sinalização Wnt; Proteínas de Sinalização YAP

Palavras-chave

Acinar-to-Ductal Metaplasia; Inflammation; KRAS; Wnt/ß-Catenin Signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Lesões Pré-Cancerosas / Carcinoma de Células Acinares / Carcinoma Ductal Pancreático / Quinase 2 de Adesão Focal / Beta Catenina Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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