Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival.

Nagy, Ádám; Osz, Ágnes; Budczies, Jan; Krizsán, Szilvia; Szombath, Gergely; Demeter, Judit; Bödör, Csaba; Gyorffy, Balázs.

Afiliação

Nagy Á; MTA TTK Lendület Cancer Biomarker Research Group, Hungarian Academy of Sciences Research Centre for Natural Sciences, Institute of Enzymology, Magyar Tudósok körútja 2, 1117 Budapest, Hungary.
Osz Á; Semmelweis University 2nd Dept. of Pediatrics, Tuzoltó utca 7-9, 1094 Budapest, Hungary.
Budczies J; MTA TTK Lendület Cancer Biomarker Research Group, Hungarian Academy of Sciences Research Centre for Natural Sciences, Institute of Enzymology, Magyar Tudósok körútja 2, 1117 Budapest, Hungary.
Krizsán S; Semmelweis University 2nd Dept. of Pediatrics, Tuzoltó utca 7-9, 1094 Budapest, Hungary.
Szombath G; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Demeter J; MTA-SE Lendület Molecular Oncohematology Research Group, 1st Department of Pathology, and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Bödör C; 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Gyorffy B; 1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

J Adv Res ; 20: 105-116, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31333881

Palavras-chave

AML, acute myeloid leukemia; Acute myeloid leukemia; Clinical samples; FAB classification, FrenchAmericanBritish classification; FC, fold change; Gene expression; HOX genes; HOX, homeobox; HR, hazard ratio; ITD, internal tandem duplication; MEIS, myeloid ecotropic viral integration site; Mutation; NCBI GEO, National Center for Biotechnology Gene expression Omnibus; OS, overall survival; PBX, pre-B-cell leukemia homeobox; Survival; TCGA, The Cancer Genome Atlas; WHO, World Health Organization; qPCR, quantitative polymerase chain reaction

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article