Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB-induced immunosuppression and impairs skin tumor growth in mice.
Eur J Immunol
; 49(11): 2095-2102, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31334839
ABSTRACT
There is increasing evidence of the relevant connection and regulation between the gut and skin immune axis. In fact, oral administration of lipoteichoic acid (LTA) from Lactobacillus rhamnosus GG (LGG) prevents the development of UV-induced skin tumors in chronically exposed mice. Here we aim to evaluate whether this LTA is able to revert UV-induced immunosuppression as a mechanism involved in its anti-tumor effect and whether it has an immunotherapeutic effect against cutaneous squamous cell carcinoma. Using a mouse model of contact hypersensitivity, we demonstrate that LTA overcomes UV-induced skin immunosuppression. This effect was in part achieved by modulating the phenotype of lymph node resident dendritic cells (DC) and the homing of skin migratory DC. Importantly, oral LTA reduced significantly the growth of established skin tumors once UV radiation was discontinued, demonstrating that it has a therapeutic, besides the already demonstrated preventive antitumor effect. The data presented here strongly indicates that oral administration of LTA represents a promising immunotherapeutic approach for different conditions in which the skin immune system is compromised.
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MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Ácidos Teicoicos
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Raios Ultravioleta
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Carcinoma de Células Escamosas
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Lipopolissacarídeos
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Lacticaseibacillus rhamnosus
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Antineoplásicos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article