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A multipixel diffuse correlation spectroscopy system based on a single photon avalanche diode array.
Johansson, Johannes D; Portaluppi, Davide; Buttafava, Mauro; Villa, Federica.
Afiliação
  • Johansson JD; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
  • Portaluppi D; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
  • Buttafava M; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
  • Villa F; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
J Biophotonics ; 12(11): e201900091, 2019 11.
Article em En | MEDLINE | ID: mdl-31339649
ABSTRACT
The autocorrelation of laser speckles from coherent near infrared light is used for noninvasive estimates of relative changes in blood perfusion in techniques such as laser Doppler flowmetry (LDF) and diffuse correlation spectroscopy (DCS). In this study, a 2D array of single photon avalanche diodes (SPADs) was used to combine the strengths of multiple detectors in LDF with high light sensitivity in DCS. The system was tested on milk phantoms with varying detector fiber diameter (200 and 600 µm), source-detector fiber separation (4.6-10.2 mm), fiber-SPAD distance (2.5-36.5 mm), contiguous measurement time per repetition for the autocorrelation (1-33 ms) and temperature (15.6-46.7°C). An in vivo blood occlusion test was also performed. The multipixel approach improved signal-to-noise ratio (SNR) and, in our setup, the use of a multimode detector fiber was beneficial for SNR. In conclusion, the multipixel system works, but improvements and further studies regarding, for example, the data acquisition and optimal settings are still needed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise Espectral / Fluxometria por Laser-Doppler / Fótons Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise Espectral / Fluxometria por Laser-Doppler / Fótons Idioma: En Ano de publicação: 2019 Tipo de documento: Article