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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Watson, Edmond R; Grace, Christy R R; Zhang, Wei; Miller, Darcie J; Davidson, Iain F; Prabu, J Rajan; Yu, Shanshan; Bolhuis, Derek L; Kulko, Elizaveta T; Vollrath, Ronnald; Haselbach, David; Stark, Holger; Peters, Jan-Michael; Brown, Nicholas G; Sidhu, Sachdev S; Schulman, Brenda A.
Afiliação
  • Watson ER; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Grace CRR; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Zhang W; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Miller DJ; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5S3E1.
  • Davidson IF; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S3E1.
  • Prabu JR; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Yu S; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria.
  • Bolhuis DL; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Kulko ET; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Vollrath R; Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599.
  • Haselbach D; Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599.
  • Stark H; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Peters JM; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria.
  • Brown NG; Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
  • Sidhu SS; Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
  • Schulman BA; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria.
Proc Natl Acad Sci U S A ; 116(35): 17280-17289, 2019 08 27.
Article em En | MEDLINE | ID: mdl-31350353
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliubiquitina / Enzimas de Conjugação de Ubiquitina / Ubiquitinação / Ciclossomo-Complexo Promotor de Anáfase Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliubiquitina / Enzimas de Conjugação de Ubiquitina / Ubiquitinação / Ciclossomo-Complexo Promotor de Anáfase Idioma: En Ano de publicação: 2019 Tipo de documento: Article