1 H-31 P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis.
Ann Clin Transl Neurol
; 6(7): 1332-1337, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31353859
ABSTRACT
Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive-MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biotina
/
Esclerose Múltipla
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article