Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases.
Neurol Neuroimmunol Neuroinflamm
; 6(5): e592, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31355325
ABSTRACT
Objective:
To describe novel clinical features of GlyRα1-IgG-positive patients.Methods:
Patients with a positive serum GlyRα1-IgG were identified during a 2-year period from July 2016 to December 2018 at 2 academic centers and followed prospectively. All patients in this series were evaluated in the Neuroimmunology and Autoimmune Neurology clinics at the University of Utah or the University of Colorado.Results:
Thirteen of 17 patients had phenotypes more typically associated with glutamic acid decarboxylase (GAD65) antibody syndromes, consisting of stiff-person syndrome (SPS) with parkinsonism or cerebellar signs. One patient with parkinsonism had a presentation similar to rapidly progressive multiple system atrophy with severe dysautonomia. Ten of 17 patients had various visual symptoms including visual snow, spider web-like images forming shapes and 3-dimensional images, palinopsia, photophobia, visual hallucinations, synesthesia, and intermittent diplopia. Three of 17 patients presented with primarily autoimmune epilepsy accompanied by psychiatric symptoms.Conclusions:
Clinicians should consider testing for GlyR antibodies in GAD65 antibody-negative or low-positive GAD65 antibody patients with SPS-like presentations, especially in the setting of atypical features such as visual disturbances, parkinsonism, or epilepsy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Autoanticorpos
/
Imunoglobulina G
/
Proteínas Nucleares
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article