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Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1ß is associated with changes in expression of beta-cell maturity genes and associated histone modifications.
Ibarra Urizar, Adriana; Prause, Michala; Wortham, Matthew; Sui, Yinghui; Thams, Peter; Sander, Maike; Christensen, Gitte Lund; Billestrup, Nils.
Afiliação
  • Ibarra Urizar A; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Prause M; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Wortham M; Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Sui Y; Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Thams P; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Sander M; Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Christensen GL; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark; Department of Biomedical Laboratory Science, Metropolitan University College, Copenhagen, 2200, Denmark.
  • Billestrup N; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark; Lead Contact Nils Billestrup, Department of Biomedical Science, University of Copenhagen, Copenhagen, 2200, Denmark. Electronic address: billestrup@sund.ku.dk.
Mol Cell Endocrinol ; 496: 110524, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31362031
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Processamento de Proteína Pós-Traducional / Regulação da Expressão Gênica / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Interleucina-1beta Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Processamento de Proteína Pós-Traducional / Regulação da Expressão Gênica / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Interleucina-1beta Idioma: En Ano de publicação: 2019 Tipo de documento: Article