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Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease.
Chen, Zhen; Shao, Tuo; Gao, Wei; Fu, Hualong; Collier, Thomas Lee; Rong, Jian; Deng, Xiaoyun; Yu, Qingzhen; Zhang, Xiaofei; Davenport, April T; Daunais, James B; Wey, Hsiao-Ying; Shao, Yihan; Josephson, Lee; Qiu, Wen-Wei; Liang, Steven.
Afiliação
  • Chen Z; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Shao T; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Gao W; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
  • Fu H; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Collier TL; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Rong J; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Deng X; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Yu Q; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Zhang X; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Davenport AT; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA.
  • Daunais JB; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA.
  • Wey HY; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Shao Y; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73019, USA.
  • Josephson L; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Qiu WW; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
  • Liang S; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
ChemMedChem ; 14(17): 1580-1585, 2019 09 04.
Article em En | MEDLINE | ID: mdl-31365783
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Pirimidinas / Morfolinas / Compostos Radiofarmacêuticos / Inibidores de Proteínas Quinases / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Pirimidinas / Morfolinas / Compostos Radiofarmacêuticos / Inibidores de Proteínas Quinases / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Idioma: En Ano de publicação: 2019 Tipo de documento: Article