Low resting diffusion capacity, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.
J Appl Physiol (1985)
; 127(4): 1107-1116, 2019 10 01.
Article
em En
| MEDLINE
| ID: mdl-31369329
ABSTRACT
The mechanisms linking reduced diffusing capacity of the lung for carbon monoxide (DlCO) to dyspnea and exercise intolerance across the chronic obstructive pulmonary disease (COPD) continuum are poorly understood. COPD progression generally involves both DlCO decline and worsening respiratory mechanics, and their relative contribution to dyspnea has not been determined. In a retrospective analysis of 300 COPD patients who completed symptom-limited incremental cardiopulmonary exercise tests, we tested the association between peak oxygen-uptake (VÌo2), DlCO, and other resting physiological measures. Then, we stratified the sample into tertiles of forced expiratory volume in 1 s (FEV1) and inspiratory capacity (IC) and compared dyspnea ratings, pulmonary gas exchange, and respiratory mechanics during exercise in groups with normal and low DlCO [i.e., Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Descanso
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Exercício Físico
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Troca Gasosa Pulmonar
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Capacidade Inspiratória
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Tolerância ao Exercício
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Doença Pulmonar Obstrutiva Crônica
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Dispneia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article