Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation.

Grishin, Alexander V; Shestak, Nikita V; Lavrova, Natalia V; Lyashchuk, Alexander M; Popova, Liubov I; Strukova, Natalia V; Generalova, Maria S; Ryazanova, Anna V; Polyakov, Nikita B; Galushkina, Zoya M; Soboleva, Lyubov A; Boksha, Irina S; Karyagina, Anna S; Lunin, Vladimir G

Grishin, Alexander V; Shestak, Nikita V; Lavrova, Natalia V; Lyashchuk, Alexander M; Popova, Liubov I; Strukova, Natalia V; Generalova, Maria S; Ryazanova, Anna V; Polyakov, Nikita B; Galushkina, Zoya M; Soboleva, Lyubov A; Boksha, Irina S; Karyagina, Anna S; Lunin, Vladimir G.

Afiliação

Grishin AV; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia. grishin-a1@yandex.ru.
Shestak NV; All-Russia Research Institute of Agricultural Biotechnology, 127550 Moscow, Russia. grishin-a1@yandex.ru.
Lavrova NV; MIREA Russian Technological University, 119048 Moscow, Russia.
Lyashchuk AM; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Popova LI; All-Russia Research Institute of Agricultural Biotechnology, 127550 Moscow, Russia.
Strukova NV; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Generalova MS; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Ryazanova AV; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Polyakov NB; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Galushkina ZM; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Soboleva LA; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Boksha IS; Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia.
Karyagina AS; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Lunin VG; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.

Molecules ; 24(16)2019 Aug 09.

Article em En | MEDLINE | ID: mdl-31395814

Assuntos

Proteínas de Bactérias; Lisostafina; Proteínas Recombinantes de Fusão; Albumina Sérica/química; Staphylococcus aureus/crescimento & desenvolvimento; Animais; Proteínas de Bactérias/química; Proteínas de Bactérias/genética; Proteínas de Bactérias/farmacocinética; Proteínas de Bactérias/farmacologia; Feminino; Lisostafina/química; Lisostafina/genética; Lisostafina/farmacocinética; Lisostafina/farmacologia; Ratos; Ratos Wistar; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/farmacocinética; Proteínas Recombinantes de Fusão/farmacologia

Palavras-chave

albumin-binding domain; antibiotic resistance; endolysin; lysin; lysostaphin; pharmacodynamics; pharmacokinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Proteínas de Bactérias / Proteínas Recombinantes de Fusão / Albumina Sérica / Lisostafina Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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