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The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
Kaustov, Lilia; Lemak, Alexander; Wu, Hong; Faini, Marco; Fan, Lixin; Fang, Xianyang; Zeng, Hong; Duan, Shili; Allali-Hassani, Abdellah; Li, Fengling; Wei, Yong; Vedadi, Masoud; Aebersold, Ruedi; Wang, Yunxing; Houliston, Scott; Arrowsmith, Cheryl H.
Afiliação
  • Kaustov L; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, ON M5G 2M9, Canada.
  • Lemak A; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
  • Wu H; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, ON M5G 2M9, Canada.
  • Faini M; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada.
  • Fan L; Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, 8093 Zürich, Switzerland.
  • Fang X; The Small-Angel X-ray Scattering Core Facility, Center for Cancer Research of National Cancer Institute, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc. Frederick, MD 21702, USA.
  • Zeng H; The Small-Angel X-ray Scattering Core Facility, Center for Cancer Research of National Cancer Institute, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc. Frederick, MD 21702, USA.
  • Duan S; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada.
  • Allali-Hassani A; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, ON M5G 2M9, Canada.
  • Li F; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada.
  • Wei Y; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada.
  • Vedadi M; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada.
  • Aebersold R; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada.
  • Wang Y; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
  • Houliston S; Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, 8093 Zürich, Switzerland.
  • Arrowsmith CH; Faculty of Science, University of Zürich, 8057 Zürich, Switzerland.
Nucleic Acids Res ; 47(17): 9433-9447, 2019 09 26.
Article em En | MEDLINE | ID: mdl-31400120
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Histona-Lisina N-Metiltransferase / Proteínas de Ligação a DNA / Proteína de Leucina Linfoide-Mieloide Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Histona-Lisina N-Metiltransferase / Proteínas de Ligação a DNA / Proteína de Leucina Linfoide-Mieloide Idioma: En Ano de publicação: 2019 Tipo de documento: Article