Recombinant Subunit Rotavirus Trivalent Vaccine Candidate: Physicochemical Comparisons and Stability Evaluations of Three Protein Antigens.

Agarwal, Sanjeev; Hickey, John M; Sahni, Neha; Toth, Ronald T; Robertson, George A; Sitrin, Robert; Cryz, Stanley; Joshi, Sangeeta B; Volkin, David B

Agarwal, Sanjeev; Hickey, John M; Sahni, Neha; Toth, Ronald T; Robertson, George A; Sitrin, Robert; Cryz, Stanley; Joshi, Sangeeta B; Volkin, David B.

Afiliação

Agarwal S; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Hickey JM; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Sahni N; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Toth RT; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Robertson GA; The Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia 20001.
Sitrin R; The Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia 20001.
Cryz S; The Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia 20001.
Joshi SB; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Volkin DB; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047. Electronic address: volkin@ku.edu.

J Pharm Sci ; 109(1): 380-393, 2020 01.

Article em En | MEDLINE | ID: mdl-31400347

Assuntos

Antígenos Virais/genética; Infecções por Rotavirus/prevenção & controle; Vacinas contra Rotavirus; Rotavirus/imunologia; Composição de Medicamentos; Estabilidade de Medicamentos; Escherichia coli/genética; Proteínas Recombinantes de Fusão/genética; Vacinas contra Rotavirus/química; Vacinas contra Rotavirus/genética; Vacinas contra Rotavirus/imunologia; Vacinas de Subunidades Antigênicas/química; Vacinas de Subunidades Antigênicas/genética; Vacinas de Subunidades Antigênicas/imunologia; Vacinas Sintéticas/química; Vacinas Sintéticas/genética; Vacinas Sintéticas/imunologia; Proteínas não Estruturais Virais/genética

Palavras-chave

aggregation; characterization; formulation; mass spectrometry; rotavirus; stability; vaccine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Rotavirus / Vacinas contra Rotavirus / Antígenos Virais Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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