(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp.
J Org Chem
; 84(17): 11203-11209, 2019 09 06.
Article
em En
| MEDLINE
| ID: mdl-31409073
ABSTRACT
Two new dimeric compounds of the alternariol class, (±)-alternarlactones A (1) and B (2), were isolated along with 11 known compounds from the fungus Alternaria alternata P1210. Their structures were elucidated with the assistance of long-range HSQMBC to address inadequate cross-peaks in HMBC that result from the highly dense quaternary carbons, as well as theoretical calculations. All isolated altenuisol derivatives were screened for their antiparasitic activities, which provide a preliminary structure-activity relationship of this class of compounds against neglected tropical diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dimerização
/
Alternaria
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Plantas Tolerantes a Sal
/
Lactonas
/
Antiparasitários
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article