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Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation.
Zhao, Peng; Han, Sheng-Na; Arumugam, Suyavaran; Yousaf, Muhammad Nadeem; Qin, Yanqin; Jiang, Joy X; Torok, Natalie Julia; Chen, Yonglin; Mankash, Mohd Salah; Liu, Junbao; Li, Jiansheng; Iwakiri, Yasuko; Ouyang, Xinshou.
Afiliação
  • Zhao P; Section of Digestive Diseases, Yale University School of medicine, New Haven, Connecticut.
  • Han SN; Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Arumugam S; Section of Digestive Diseases, Yale University School of medicine, New Haven, Connecticut.
  • Yousaf MN; Department of Pharmacology, Basic Medical College, Zhengzhou University, Zhengzhou, China.
  • Qin Y; Section of Digestive Diseases, Yale University School of medicine, New Haven, Connecticut.
  • Jiang JX; Section of Digestive Diseases, Yale University School of medicine, New Haven, Connecticut.
  • Torok NJ; Section of Digestive Diseases, Yale University School of medicine, New Haven, Connecticut.
  • Chen Y; Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Mankash MS; Department of Internal Medicine, University of California, Davis, Sacramento, California.
  • Liu J; Department of Gastroenterology and Hepatology, Stanford University and Veterans Affairs, Palo Alto, Stanford, California.
  • Li J; Section of Digestive Diseases, Yale University School of medicine, New Haven, Connecticut.
  • Iwakiri Y; Section of Digestive Diseases, Yale University School of medicine, New Haven, Connecticut.
  • Ouyang X; The People's Hospital of Henan Province, Zhengzhou, China.
Am J Physiol Gastrointest Liver Physiol ; 317(4): G387-G397, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31411894

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Ativação Transcricional / Hepatócitos / Digoxina / Inibidores Enzimáticos / Hepatopatia Gordurosa não Alcoólica Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Ativação Transcricional / Hepatócitos / Digoxina / Inibidores Enzimáticos / Hepatopatia Gordurosa não Alcoólica Idioma: En Ano de publicação: 2019 Tipo de documento: Article