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A meta-analysis of genome-wide association studies identifies multiple longevity genes.
Deelen, Joris; Evans, Daniel S; Arking, Dan E; Tesi, Niccolò; Nygaard, Marianne; Liu, Xiaomin; Wojczynski, Mary K; Biggs, Mary L; van der Spek, Ashley; Atzmon, Gil; Ware, Erin B; Sarnowski, Chloé; Smith, Albert V; Seppälä, Ilkka; Cordell, Heather J; Dose, Janina; Amin, Najaf; Arnold, Alice M; Ayers, Kristin L; Barzilai, Nir; Becker, Elizabeth J; Beekman, Marian; Blanché, Hélène; Christensen, Kaare; Christiansen, Lene; Collerton, Joanna C; Cubaynes, Sarah; Cummings, Steven R; Davies, Karen; Debrabant, Birgit; Deleuze, Jean-François; Duncan, Rachel; Faul, Jessica D; Franceschi, Claudio; Galan, Pilar; Gudnason, Vilmundur; Harris, Tamara B; Huisman, Martijn; Hurme, Mikko A; Jagger, Carol; Jansen, Iris; Jylhä, Marja; Kähönen, Mika; Karasik, David; Kardia, Sharon L R; Kingston, Andrew; Kirkwood, Thomas B L; Launer, Lenore J; Lehtimäki, Terho; Lieb, Wolfgang.
Afiliação
  • Deelen J; Max Planck Institute for Biology of Ageing, 50866, Cologne, Germany. Joris.Deelen@age.mpg.de.
  • Evans DS; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands. Joris.Deelen@age.mpg.de.
  • Arking DE; California Pacific Medical Center Research Institute, San Francisco, CA, 94158, USA. DEvans@sfcc-cpmc.net.
  • Tesi N; McKusick-Nathans Institute of Genetic Medicine, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Nygaard M; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
  • Liu X; Department of Clinical Genetics, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
  • Wojczynski MK; Delft Bioinformatics Lab, Delft University of Technology, 2600 GA, Delft, The Netherlands.
  • Biggs ML; The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
  • van der Spek A; BGI-Shenzhen, Shenzhen, 518083, China.
  • Atzmon G; China National Genebank, BGI-Shenzhen, Shenzhen, 518120, China.
  • Ware EB; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
  • Sarnowski C; Department of Biostatistics, University of Washington, Seattle, WA, 98115, USA.
  • Smith AV; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
  • Seppälä I; Department of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, The Netherlands.
  • Cordell HJ; Department of Biology, Faculty of Natural Science, University of Haifa, Haifa, 3498838, Israel.
  • Dose J; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
  • Amin N; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, 48104, USA.
  • Arnold AM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
  • Ayers KL; School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Barzilai N; Icelandic Heart Association, 201, Kópavogur, Iceland.
  • Becker EJ; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
  • Beekman M; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
  • Blanché H; Institute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
  • Christensen K; Department of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, The Netherlands.
  • Christiansen L; Department of Biostatistics, University of Washington, Seattle, WA, 98115, USA.
  • Collerton JC; Sema4, a Mount Sinai venture, Stamford, CT, 06902, USA.
  • Cubaynes S; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
  • Cummings SR; Bioinformatics Program, Boston University, Boston, MA, 02118, USA.
  • Davies K; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.
  • Debrabant B; Fondation Jean Dausset-CEPH, 75010, Paris, France.
  • Deleuze JF; The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
  • Duncan R; Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000, Odense C, Denmark.
  • Faul JD; Department of Clinical Genetics, Odense University Hospital, 5000, Odense C, Denmark.
  • Franceschi C; The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
  • Galan P; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark.
  • Gudnason V; Institute of Health & Society, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
  • Harris TB; MMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University, 34095, Montpellier, France.
  • Huisman M; California Pacific Medical Center Research Institute, San Francisco, CA, 94158, USA.
  • Hurme MA; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
  • Jagger C; Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
  • Jansen I; Fondation Jean Dausset-CEPH, 75010, Paris, France.
  • Jylhä M; Centre National de Recherche en Génomique Humaine, CEA-Institut de Biologie François Jacob, 91000, Evry, France.
  • Kähönen M; Institute of Health & Society, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
  • Karasik D; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
  • Kardia SLR; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, 48104, USA.
  • Kingston A; Department of Applied Mathematics and Centre of Bioinformatics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, 603022, Russia.
  • Kirkwood TBL; IRCCS Institute of Neurological Sciences of Bologna (ISNB), 40124, Bologna, Italy.
  • Launer LJ; EREN, UMR U1153 Inserm/U1125 Inra/Cnam/Paris 13, Université Paris 13, CRESS, 93017, Bobigny, France.
  • Lehtimäki T; Icelandic Heart Association, 201, Kópavogur, Iceland.
  • Lieb W; Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland.
Nat Commun ; 10(1): 3669, 2019 08 14.
Article em En | MEDLINE | ID: mdl-31413261
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteína E2 / Apolipoproteína E4 / Proteínas de Choque Térmico / Longevidade Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteína E2 / Apolipoproteína E4 / Proteínas de Choque Térmico / Longevidade Idioma: En Ano de publicação: 2019 Tipo de documento: Article